What is CagA gene?

What is CagA gene?

Helicobacter pylori virulence factor CagA (cytotoxin-associated gene A) is a 120–145kDa protein encoded on the 40kb cag pathogenicity island (PAI). H. pylori strains can be divided into CagA positive or negative strains.

What causes Stomachcancer?

The main cause of stomach cancer is a genetic mutation (change) in the cells of the stomach, which causes the cells to grow rapidly and eventually form a tumor. Risk factors that can increase a person’s chance of getting stomach cancer include: Family history. Smoking.

What is cytotoxin-associated gene A?

Core tip: Cytotoxin-associated gene A (CagA) protein encoded by cag pathogenicity island of Helicobacter pylori is a bacterium-derived oncoprotein and is strongly associated with the gastric mucosa-associated lymphoid tissue (MALT) lymphoma.

What is CagA and VacA?

Two of the virulence factors that have been implicated in this process are cytotoxin-associated gene A (CagA) and vacuolating cytotoxin A (VacA), which are cytotoxins that are injected and secreted by H. pylori, respectively.

What does CagA do to cells?

Through the interaction, CagA disrupts adherens junctions by perturbing the adaptor function of Crk in cell signaling. CagA binds to Grb2 via the EPIYA-containing region and thus aberrantly activates the Ras signaling pathway to stimulate abnormal cell proliferation.

What are the virulence factors of Helicobacter pylori?

The virulence factors of H. pylori can be categorized to be related with 3 major pathogenic processes, including colonization, immune escape and disease induction (Table 1). The virulence factors responsible for establishing colonization include urease, flagella, chemotaxis system, and adhesins [2, 3].

What is adenocarcinoma stomach?

Adenocarcinomas. Most cancers of the stomach (about 90% to 95%) are adenocarcinomas. These cancers develop from the gland cells in the innermost lining of the stomach (the mucosa). If you are told you have stomach cancer (or gastric cancer), it will almost always be an adenocarcinoma.

What is Vac A in H. pylori?

H. pylori secretes many proteinaceous factors that are important for initial colonization and subsequent persistence in the host stomach. One of the major protein toxins secreted by H. pylori is the Vacuolating cytotoxin A (VacA).

What does CAG a do in H. pylori?

CagA is one of the most studied pathogenicity factors of the bacterial pathogen Helicobacter pylori. It is injected into host cells via the H. pylori cag-Type IV secretion system. Due to its association with gastric cancer, CagA is classified as oncogenic protein.

Can chronic gastritis be cured?

In cases where the cause is immune system related or complex, it may not be possible to cure the gastritis completely. We can cure gastritis permanently by getting rid of the cause of the gastritis.