What is the function of IL-15?
Interleukin-15 (IL-15) is a pleiotropic cytokine with a broad range of biological functions in many diverse cell types. It plays a major role in the development of inflammatory and protective immune responses to microbial invaders and parasites by modulating immune cells of both the innate and adaptive immune systems.
How is IL-15 produced?
Interleukin 15 (IL-15) is a cytokine that is produced by monocytes. It is an activator of T lymphocytes and a stimulator of natural killer cell proliferation and activation. Furthermore, IL-15 induces cytokine production by monocytes and polymorphonuclear cells and stimulates the antimicrobial activity of phagocytes.
How do I raise my IL-15?
Various other preclinical approaches have been examined to increase the efficacy of IL-15 immunotherapy, including co-administration of anti-CD40 to induce and enhance IL-15Rα expression, and the covalent binding of IL-15 to soluble IL-15Rα to mimic trans-presentation and increase the bio-stability of IL-15.
What is the role of IL 18?
IL-18 acts to promote Th1 cell activation and enhance the cytotoxic activity of CD8+ T cells and natural killer (NK) cells by upregulation of FasL. IL-18 is a strong inducer of inflammatory cytokines, especially IFN-γ (its original name was “interferon-γ–inducing factor”).
Is IL-15 anti inflammatory?
What does IL-15 do to T cells?
IL-15 induces the activation, the proliferation and the survival of T cells and contributes to generation and maintenance of high-avidity, antigen-specific CD8+ memory T cells in the long-term. In addition, IL-15 is involved in the development, the persistence and the activation of NK and NKT as well as γ/δT cells (2).
Do macrophages produce IL-15?
4.2. IL-15 mRNA is expressed by mouse monocytes and macrophages when primed with IFN-γ and triggered with various microbial agents and this expression is not down regulated by inhibitory cytokines such as IL-13 and TGF-β .
Is IL 21 inflammatory?
While the IL-21/IL-21R pathway has been shown to be important in protection against several microbial pathogens, the IL-21/IL-21R signaling axis has been linked to excessive inflammation and associated pathogenesis observed during infectious and non-infectious inflammatory conditions (Stolfi et al., 2011; Tortola et al …