What causes ocular pemphigoid?
Pemphigoid is a chronic scarring disease of the conjunctiva. It may be caused by drugs or eye drops but in most patients it is caused by too much activity of the immune system damaging the tissue under the conjunctiva.
How does pemphigoid affect the eyes?
Ocular Citatrical Pemphigoid/Mucous Membrane Pemphigoid The inflammatory lesions on the ocular surface may result in scarring, loss of tear film, adhesions of the lids to the eyeball, corneal ulcers, and perforation. The frequent scarring that often occurs in this condition can lead to severe vision loss.
How is ocular pemphigoid treated?
The medical management strategy for ocular cicatricial pemphigoid is to control inflammation and halt the progression of fibrosis. Treatments include topical/local therapies, systemic medications, minor procedures, and surgical intervention when necessary.
How is ocular pemphigoid correctly diagnosed?
Diagnosis can be confirmed by conjunctival biopsy showing linear antibody deposition on the basement membrane. A negative biopsy result does not rule out the diagnosis.
What are the symptoms of ocular cicatricial pemphigoid?
Symptoms of Ocular Cicatricial Pemphigoid
- eye redness.
- mucous discharge in your eyes.
- ulcers in your conjunctiva, mouth, genitals, and anus.
- hoarseness and difficulty swallowing.
What is ocular cicatricial pemphigoid?
The term ocular cicatricial pemphigoid (OCP) refers to mucous membrane pemphigoid that clinically presents as a chronic cicatrizing (scarring) conjunctivitis. Involvement of other mucosal sites and nonmucosal skin may also occur in OCP.
Can bullous pemphigoid come back?
Key Messages • The relapse rate of bullous pemphigoid ranges from 27.87% to 53% after disease remission, while the majority of relapses occur early (within 6 months) during remission.
How long does pemphigoid last?
Bullous pemphigoid often goes away on its own in a few months, but may take as many as five years to resolve. Treatment usually helps heal the blisters and ease any itching. It may include corticosteroid medications, such as prednisone, and other drugs that suppress the immune system.
How is cicatricial pemphigoid treated?
One such drug is dapsone, a sulfa-type medication that may be used to treat mild cases of MMP. Special blood tests are needed before this drug is used, however. A combination of the antibiotic drug tetracycline and nicotinamide (vitamin B3) can also be helpful in some cases of MMP.
Is ocular cicatricial pemphigoid an autoimmune disease?
Ocular cicatricial pemphigoid, also known as mucous membrane pemphigoid (MMP), is an autoimmune disease that can cause scarring in the conjunctiva of your eyes. The conjunctiva is the inside lining of your eyes that keeps a smooth surface when you blink or close your eyes.
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