Does imipramine affect the liver?
Introduction. Imipramine is a tricyclic antidepressant that continues to be widely used in the therapy of depression. Imipramine can cause mild and transient serum enzyme elevations and is rare cause of clinically apparent acute cholestatic liver injury.
How is imipramine metabolized?
Imipramine is extensively metabolized in the liver by cytochrome P450 (CYP) enzymes. Imipramine undergoes N-demethylation to its main, active metabolite desipramine via CYP2C19, CYP1A2 and CYP3A4.
Is Azepine present in imipramine structure?
Imipramine is a dibenzoazepine that is 5H-dibenzo[b,f]azepine substituted by a 3-(dimethylamino)propyl group at the nitrogen atom.
What are the side effects of imipramine?
Imipramine may cause side effects. Tell your doctor if any of these symptoms are severe or do not go away:
- weakness or tiredness.
- excitement or anxiety.
- dry mouth.
- skin more sensitive to sunlight than usual.
- changes in appetite or weight.
What is the mechanism of action of imipramine?
Imipramine is a tricyclic antidepressant that has been used since the 1950s. Its primary mechanism of action is to inhibit the reuptake of serotonin and norepinephrine, thus elevating the levels of these neurotransmitters in the brain.
When imipramine is treated with nitric acid it produces?
4. These results suggest that chronic imipramine treatment induces nitric oxide synthase gene expression in the brain, followed by augmented NO production.
Can I take amitriptyline with liver disease?
Outcome and Management Rechallenge with amitriptyline usually causes a prompt recurrence of the liver injury which can be fatal and should be avoided. Cross reactivity of hepatic injury with other tricyclic antidepressants has been described, but is not invariable.
Why is imipramine used in nocturnal enuresis?
A Cochrane review of 64 randomized trials concluded that imipramine is effective in reducing bedwetting; children treated with imipramine had one fewer wet night per week. The relapse rate is high when the medication is discontinued.
Does imipramine cause diarrhea?
The more common side effects of imipramine in adolescents and adults can include: nausea. constipation. diarrhea.
How is desipramine metabolized?
Desipramine is extensively metabolized in the liver by CYP2D6 (major) and CYP1A2 (minor) to 2-hydroxydesipramine, an active metabolite. 2-hydroxydesipramine is thought to retain some amine reuptake inhibition and may possess cardiac depressant activity.