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What is myocardial ischemia reperfusion injury?

What is myocardial ischemia reperfusion injury?

Myocardial reperfusion injury is defined as the death of myocytes, which were alive at the time of reperfusion, as a direct result of one or more events initiated by reperfusion.

What are causes of myocardial reperfusion and injury?

Lethal myocardial reperfusion injury. The major contributory factors are discussed below and include oxidative stress, calcium overload, mitochondrial permeability transition pore (MPTP) opening, and hypercontracture (3).

What causes damage during ischemia and reperfusion?

Reperfusion injury, sometimes called ischemia-reperfusion injury (IRI) or reoxygenation injury, is the tissue damage caused when blood supply returns to tissue (re- + perfusion) after a period of ischemia or lack of oxygen (anoxia or hypoxia).

What are examples of reperfusion injury?

Table 1

Affected organ Example of clinical manifestation
Circulatory arrest Hypoxic brain injury; multiple organ failure; acute kidney injury
Sickle cell disease Acute chest syndrome; pulmonary hypertension, priapism, acute kidney injury
Sleep apnea Hypertension; diabetes
Ischemia and reperfusion during major surgery

How serious is myocardial ischemia?

Myocardial ischemia can lead to serious complications, including: Heart attack. If a coronary artery becomes completely blocked, the lack of blood and oxygen can lead to a heart attack that destroys part of the heart muscle. The damage can be serious and sometimes fatal.

What does ischemic injury mean?

Ischemic injury is caused by diminished or absent blood flow. The main mechanism of injury in ischemia is hypoxia (as described above).

What happens during ischemia?

Causes of myocardial ischemia Myocardial ischemia occurs when blood flow to your heart is reduced, preventing the heart muscle from receiving enough oxygen. The reduced blood flow is usually the result of a partial or complete blockage of your heart’s arteries (coronary arteries).