What inactivates EGFR?
From the work in tissue culture, two strategies have emerged for inhibiting uncontrolled cell growth arising from EGFR overexpression or hyperactivation—monoclonal antibodies (MAbs) and tyrosine kinase inhibitors (TKIs).
How is EGFR inhibited?
The two primary means of inhibiting the EGFR pathway are small molecule tyrosine kinase inhibitors (TKIs) and monoclonal antibodies (mAbs). EGFR TKIs (molecular weight 400–500 daltons) exert their effects intracellularly.
What is the role of EGFR?
Normal Function The EGFR gene provides instructions for making a receptor protein called the epidermal growth factor receptor, which spans the cell membrane so that one end of the protein remains inside the cell and the other end projects from the outer surface of the cell.
What is the EGFR family?
The epidermal growth factor receptor family consists of four related receptor tyrosine kinases: EGFR (ErbB1, HER1), ErbB2 (HER2, neu in rodents), ErbB3 (HER3), and ErbB4 (HER4) (31).
What type of drugs are EGFR inhibitors?
EGFR inhibitors used in NSCLC with EGFR gene mutations
- Erlotinib (Tarceva)
- Afatinib (Gilotrif)
- Gefitinib (Iressa)
- Osimertinib (Tagrisso)
- Dacomitinib (Vizimpro)
How long do EGFR inhibitors work?
EGFR inhibitors that target cells with the T790M mutation EGFR inhibitors can often shrink tumors for several months or more. But eventually these drugs stop working for most people, usually because the cancer cells develop another mutation in the EGFR gene. One such mutation is known as T790M.
Is HER2 the same as EGFR?
5.5. HER2 belongs to the human epidermal growth factor receptor family, which includes EGFR (alias HER1), HER3, and HER4. HER2 works as an oncogene in several cancers including breast cancers, manifesting its effect of carcinogenesis mainly by overexpression or due to gene amplification.
Is EGFR a tumor suppressor?
Researchers from Yale are referring to the EGFR gene as the “silencer” gene, because, they say, it “silences genes that typically suppress tumors.” The team, led by Narendra Wajapayee, assistant professor of pathology and a member of Yale Cancer Center, report in a June 23 press release, that this critical finding “may …