Helpful tips

Do platelet transfusions cause fever?

Do platelet transfusions cause fever?

Fever occurs more commonly with platelet transfusion (10-30%) than red cell transfusion (1-2%). It is important to distinguish from fever due to the patient’s underlying disease or infection (check pretransfusion temperature).

Can transfusions cause fever?

Developing a fever after a transfusion is not serious. A fever is your body’s response to the white blood cells in the transfused blood. However, it can be a sign of a serious reaction if the patient is also experiencing nausea or chest pain.

What is the most common cause of febrile transfusion reactions?

Nonhemolytic febrile transfusion reactions are usually caused by cytokines from leukocytes in transfused red cell or platelet components, causing fever, chills, or rigors. In the transfusion setting, a fever is defined as a temperature elevation of 1º C or 2º F.

What are the signs and symptoms of a transfusion reaction?

The most common signs and symptoms include fever, chills, urticaria (hives), and itching. Some symptoms resolve with little or no treatment. However, respiratory distress, high fever, hypotension (low blood pressure), and red urine (hemoglobinuria) can indicate a more serious reaction.

How common are platelet transfusion reactions?

The risk of allergic reactions is between 0.09 and 21% in patients who receive platelet transfusions [16].

How do you treat a fever after a blood transfusion?

A fever is often a sign that the patient’s body is reacting to white blood cells, plasma, or platelets in the donated blood. Doctors can usually treat transfusion-related fever with medicines, such as aspirin or acetaminophen, which reduce fever. In rare cases, blood transfusions damage a person’s lungs.

Can you give blood transfusion if patient has fever?

Having a fever is not a contra-indication to a patient receiving a blood transfusion; however, if the fever is new, it is advised that medical advice should be sought before the transfusion commences in case treating the fever is deemed to be a higher priority than the transfusion.

What are febrile transfusion reactions?

A febrile non-hemolytic transfusion reactions (FNHTR) is defined as a temperature increase of 1°C over 37°C occurring during or after the transfusion of blood components. FNHTRs are more common in the transfusion of platelets.

How does febrile transfusion reaction occur?

Most febrile reactions that occur during transfusion of red blood cells are caused by the interaction of leukocyte antibodies in the recipient’s plasma with donor leukocytes, stimulating the release of pro-inflammatory cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF).

How do you prevent a febrile transfusion reaction?

The best way to prevent severe febrile reactions is to use prestorage leukocyte reduced red blood cells and apheresis platelets. If a patient continues to have febrile reactions to leukocyte reduced single donor platelets, it may be helpful to remove plasma from the platelet unit immediately prior to transfusion.