What type of protein is ERK1?
Abstract. ERK1/2 (extracellular signal-regulated protein kinases) are the nodal proteins that regulate diverse cellular functions primarily in response to activation from receptor tyrosine kinases (RTKs).
What is ERK1 and ERK2?
Protein sequences of ERK1 and ERK2 are 84% identical in a given mammal; human ERK1 is larger than human ERK2 due to an extension of 17 amino-acids at its N-terminal and 2 amino-acids at its C-terminal.
What does ERK1 2 stand for?
extracellular signal-regulated kinase 1/2
Abstract. The extracellular signal-regulated kinase 1/2 (ERK1/2) cascade is a central signaling pathway that regulates a wide variety of stimulated cellular processes, including mainly proliferation, differentiation, and survival, but apoptosis and stress response as well.
Is ERK1 2 a protein?
ERK1 and ERK2 are related protein-serine/threonine kinases that participate in the Ras-Raf-MEK-ERK signal transduction cascade.
What is ERK1?
As a member of the mitogen‑activated protein kinase family, ERK1/2 (extracellular signal‑regulated protein kinase) has an important role in delivering extracellular signals to the nucleus, and these signals regulate the cell cycle, cell proliferation and cell development.
Is ERK the same as MAPK?
MAPKs were originally called “extracellular signal-regulated kinases” (ERKs) and “microtubule associated protein kinases” (MAPKs). One of the first proteins known to be phosphorylated by ERK was a microtubule-associated protein (MAP).
Is RAS a kinase?
Kinase proteins in the Ras/Raf/MEK/ERK pathway. Ras is a type of small GTP-binding protein. It is the upstream molecule in various pathways, such as MEK/ERK, PI3K/Akt, and RalEGF/Ral pathways (10).
Is ERK1 2 a transcription factor?
As a transcription factor regulator, ERK1/2 transduces signals from the cell membrane to the nucleus.
What does ERK pathway do?
Role of mitogen signaling in cell cycle progression The ERK pathway plays an important role of integrating external signals from the presence of mitogens such as epidermal growth factor (EGF) into signaling events promoting cell growth and proliferation in many mammalian cell types.
What are ERK1/2 protein-serine/threonine kinases?
Targeting ERK1/2 protein-serine/threonine kinases in human cancers ERK1 and ERK2 are key protein kinases that contribute to the Ras-Raf-MEK-ERK MAP kinase signalling module.
What is the difference between ERK1 and ERK2?
ERK1 and ERK2 are related protein-serine/threonine kinases that participate in the Ras-Raf-MEK-ERK signal transduction cascade. This cascade participates in the regulation of a large variety of processes including cell adhesion, cell cycle progression, cell migration, cell survival, differentiation, metabolism, proliferation, and transcription.
What is the function of the ERK1/2 MAP Cascade?
This cascade participates in the regulation of a large variety of processes including cell adhesion, cell cycle progression, cell migration, cell survival, differentiation, … ERK1/2 MAP kinases: structure, function, and regulation Pharmacol Res. 2012 Aug;66(2):105-43.doi: 10.1016/j.phrs.2012.04.005. Epub 2012 Apr 27. Author
What is the function of MEK1/2 in the cell cycle?
This cascade participates in the regulation of a large variety of processes including cell adhesion, cell cycle progression, cell migration, cell survival, differentiation, metabolism, proliferation, and transcription. MEK1/2 catalyze the phosphorylation of human ERK1/2 at Tyr204/187 and then Thr202/185.