Is thiopental contraindicated in asthma?
In conclusion, we would like to stress upon the fact that although bronchospasm with thiopental is a rare phenomenon it cannot be overlooked. Therefore, it is recommended that thiopental should be avoided or used cautiously in patients with a history of asthma.
Does thiopental cause bronchospasm?
Induction of anaesthesia with thiopental sometimes causes bronchospasm. Although the mechanism by which thiopental induces bronchospasm may involve cholinergic stimulation, direct spastic effect and histamine release, the spastic effects of thiopental have not been comprehensively defined.
What type of anesthetic is not recommended for asthmatic patients?
All volatile anesthetics – sevoflurane, isoflurane, desflurane, have direct bronchodilating properties. However, at higher concentrations, desflurane increases bronchial smooth muscle tone and airway resistance and should be avoided in patients with asthma.
Is thiopental an anesthesia?
Sodium thiopental is an important and medically necessary anesthetic agent that has been used for years to induce anesthesia in patients undergoing surgical procedures.
What type of drug is thiopental?
Thiopental is a barbiturate, the structure of which is that of 2-thiobarbituric acid substituted at C-5 by ethyl and sec-pentyl groups. It has a role as an anticonvulsant, a sedative, an environmental contaminant, a xenobiotic, a drug allergen and an intravenous anaesthetic. It derives from a 2-thiobarbituric acid.
What is the sedative of choice in asthmatic patients?
The most common alternative is propofol, which is attractive in patients with sudden-onset (near-fatal) asthma who may be eligible for extubation within a few hours, because it can be titrated rapidly to a deep sedation level and has rapid reversal after discontinuation; in addition, it possesses bronchodilatory …
Is Propofol safe for asthma patients?
the most appropriate anesthetics for asthmatic patients. Propofol, a widely used short-acting intravenous anaesthetic, is recognized as the ideal sedative in asthmatic patients [10,11].
How is thiopental eliminated?
Thiopental is almost completely biotransformed in the liver to mostly inactive metabolites, which are then excreted in the urine. A very small percentage of the dose is excreted unchanged in the urine.
What are the side effects of thiopental?
Tell your caregivers at once if you have severe pain while receiving thiopental. Common side effects may include: ongoing drowsiness; weak or shallow breathing; slow heartbeats; chills or shivering; sneezing, coughing, tight feeling in your throat; or.
What is pentothal (thiopental sodium)?
Pentothal (thiopental sodium) is chemically designated sodium 5-ethyl-5- (1-methylbutyl)-2-thiobarbiturate. The drug is a yellowish, hygroscopic powder, stabilized with anhydrous sodium carbonate as a buffer (60 mg/g of thiopental sodium). Diluents in Pentothal (thiopental sodium) ® Kits Ready-To-Mix Syringes and Vials
Who should not use thiopental?
You should not use thiopental if you have porphyria, liver or kidney disease, severe anemia, myasthenia gravis, asthma, a thyroid disorder, or Addison’s disease. You should not use thiopental if you are allergic to it, or if you have: porphyria (a genetic enzyme disorder that causes symptoms affecting the skin or nervous system);
What is the role of thiopental in the administration of anesthesia?
Corneal and conjunctival reflexes disappear during surgical anesthesia. When thiopental is used as the sole anesthetic agent, the desired level of anesthesia can be maintained by injection of small repeated doses as needed or by using a continuous intravenous infusion with a 0.2% or 0.4% concentration (see section 6.6).