What does UDP Glucuronosyltransferase do?
UDP-glucuronosyltransferase (UGT) enzymes catalyze the attachment of a glucuronic acid moiety to various drugs and other xenobiotics, as well as to endogenous compounds such as bilirubin. This conjugation promotes their excretion.
What induces UDP Glucuronosyltransferase?
The UDP-glucuronosyltransferases (UGTs) have long been known to be inducible by various chemicals, including drugs, although the extent of induction in general has been modest. In the present study, we determined the ability of the dietary flavonoid chrysin to induce UGT activity, protein and mRNA.
What is UDP disease?
UDP glucuronyltransferase (UDPGT) is a family of liver enzymes which conjugate drugs and endogenous compounds to the acidic sugar glucuronic acid. Diagnosis of Gilbert’s syndrome, an inherited disorder characterized by mild intermittent jaundice, is by exclusion of other hepatic or haematological disorders.
What role does UDP Glucuronosyltransferase play in bilirubin metabolism?
UDP-glucuronosyltransferase (UGT) 1A1 is the sole enzyme that can metabolize bilirubin. Human infants physiologically develop hyperbilirubinemia as the result of inadequate expression of UGT1A1 in the liver.
What is UGT1A1 gene?
The UGT1A1 gene belongs to a family of genes that provide instructions for making enzymes called UDP-glucuronosyltransferases. These enzymes perform a chemical reaction called glucuronidation, in which a compound called glucuronic acid is attached (conjugated) to one of a number of different substances.
Where is UGT1A1 located?
The UGT1A1 enzyme, primarily found in the liver, is responsible for the gluronidation of bilirubin, converting it from the toxic form of bilirubin (unconjugated bilirubin) to its nontoxic, water-soluble form (conjugated bilirubin).
What is UDP enzyme?
The UDP-glucuronosyltransferases (UGTs) are a superfamily of enzymes that catalyze the conjugation of glucuronic acid to molecules primarily to facilitate systemic elimination (Radominska-Pandya et al., 1999).
What is UDP in liver?
Abstract. The UDP glucuronosyltransferases (UGT) are a family of enzymes in which substrates include drugs, xenobiotics, and products of endogenous catabolism. The main source of most UGT enzymes is the liver, a major organ in the detoxification and inactivation of compounds.
What is the function of UDP glucuronosyltransferase?
The UDP-glucuronosyltransferase (UGT) family catalyzes the glucuronidation of the glycosyl group of a nucleotide sugar to an acceptor compound (aglycone) at a nucleophilic functional group of oxygen (eg, hydroxyl or carboxylic acid groups), nitrogen (eg, amines), sulfur (eg, thiols), and carbon, with the formation of a beta-D-glucuronide product.
Does UGT1A9 contribute to glucuronidation?
UGT1A9 is a major contributor for (R) and (S) glucuronidation in the human liver and kidney. Alleles UGT1A9*4 and UGT1A9*5 were not present in any of the subjects of Polish population.
Does UGT1A9 polymorphism affect the pharmacokinetics of mycophenolic acid and its metabolites?
UGT1A9 contributes to glucuronidation of gaboxadol in kidney and liver. the effect of UGT1A9 polymorphism on the pharmacokinetics of mycophenolic acid (MPA) and its metabolites phenolic glucuronide (MPAG) and acyl glucuronide (AcMPAG) in Chinese renal transplant
What is the UGT1A1 polymorphism?
The UGT1A promoter polymorphism is a powerful nonglobin genetic modifier in Sickle Cell Anemia that influences serum bilirubin both at baseline and on hydroxyurea therapy. polymorphism in the UGT1A1 gene promoter and its association with hyperbilirubinemia