Where is Galactosylceramide found?
Galactosylceramide (GalCer) expressed on mucosal membrane cells has been reported to be implicated in viral entry.
What are the components of Galactocerebroside?
Galactocerebroside (GalCer) is one of the simplest glycosphingolipids, comprising a single galactose residue linked to ceramide (monogalactosylceramide)….Galactocerebroside
- Axon.
- Myelin.
- Schwann Cell.
- Oligodendrocyte.
- Glycolipid.
- Glycosphingolipid.
- Ceramide.
- Sulfatide.
Is Galactosylceramide a glycolipid?
Glycolipid alpha-C-galactosylceramide is a distinct inducer of dendritic cell function during innate and adaptive immune responses of mice. Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11252-7. doi: 10.1073/pnas.
Is glucocerebrosidase and glucosylceramide the same thing?
Glucocerebroside (also called glucosylceramide) is any of the cerebrosides in which the monosaccharide head group is glucose.
What is the function of Cerebroside?
Glucocerebroside (also known as glucosylceramide) is a cerebroside in which the carbohydrate constituent is glucose. The latter is often found in non-neural tissues. In skin, it plays a part in enabling water permeability barrier function of the skin.
Is glucosylceramide a Glycosphingolipid?
In higher eukaryotes, glucosylceramide is the simplest member and precursor of a fascinating class of membrane lipids, the glycosphingolipids. These lipids display an astounding variation in their carbohydrate head groups, suggesting that glycosphingolipids serve specialized functions in recognition processes.
Is Galactosylceramide a sphingolipid?
Sphingolipid Catabolism β-Galactosidase catalyzes the degradation of galactosylceramide to galactose and ceramide within the lysosome.
How is GalCer synthesized?
GalCer is synthesized by the enzyme UDP-galactose:ceramide β-galactosyltransferase (EC 2.4.1.45) 14–16 coded by the gene Ugt8a ( Figure 3; also called Cgt ).
What is the difference between galactosylceramide synthase and CGT?
Galactosylceramide synthase (ceramide galactosyltransferase, CGT) is responsible for the synthesis of galactosylceramide from ceramide, and its sulfated derivative, sulfatide, is produced by sulfotransferase using galactosylceramide as a precursor. Both of them are enriched in myelin.
What does galcers stand for?
Human galactosylceramide synthase (GalCerS), also known as UDP-galactose:ceramide galactosyltransferase (UGT8 or CGT) (EC2.4.2.62), transfers the galactose residue from UDP-galactose to ceramide at the 1-hydroxyl moiety, thereby producing GalCer (Schulte & Stoffel, 1993; Stahl, Jurevics, Morell, Suzuki, & Popko, 1994; Fig. 3.1 ).
Is galactosylceramide synthase a compensatory component of glycolipids?
Simultaneously, the results have proposed possible compensatory mechanisms based on the modulated composition of glycolipids in the null mutants. Galactosylceramide synthase is responsible for the synthesis of galactosylceramide and its sulfated derivative, sulfatide.