Can cisplatin be given before gemcitabine?
The recommendation to administer gemcitabine prior to cisplatin is based on results of phase 1 studies in adults with solid tumors, which indicated that this administration schedule may increase the generation of platinum-DNA adducts (potentially increasing efficacy) and reduce neutropenia.
What schedule is cisplatin?
In NSCLC, the most commonly used schedule is 4 weeks with cisplatin (100 mg/m2) on day 1 or 2 and gemcitabine (1000–1250 mg/m2) on days 1, 8 and 15.
How long can you take gemcitabine and cisplatin?
One cycle of gemcitabine and cisplatin treatment is 3 weeks long. You will be considered for treatment 2 times in 3 weeks.
How is gemcitabine and cisplatin administered?
Gemcitabine (Gemzar) and cisplatin are usually given in an outpatient infusion center, allowing the person to go home afterwards. On occasion, they may be given in the hospital if someone is too sick. Gemcitabine + cisplatin is repeated every 21 or 28 days. This is known as one Cycle.
How effective is cisplatin and gemcitabine?
Tumor control (complete or partial response or stable disease) was achieved in 131 of 161 patients who received cisplatin plus gemcitabine (81.4%), as compared with 102 of 142 patients who received gemcitabine alone (71.8%) (P=0.049). One patient from each group achieved a complete response.
What is gemcitabine and cisplatin?
Listen to pronunciation. (jem-SY-tuh-been-sis-PLA-tin REH-jih-men) A chemotherapy combination used to treat malignant mesothelioma, advanced non-small cell lung cancer, advanced bladder cancer, advanced cervical cancer, pancreatic cancer, and epithelial ovarian cancer.
Does cisplatin and gemcitabine?
We conclude that gemcitabine in combination with cisplatin may be one of the most effective therapies for patients with advanced gallbladder cancer. If confirmed by others, it may provide an important therapeutic option in managing these patients who otherwise have a dismal prognosis.
What is cisplatin and gemcitabine for?
Each of the medications in the gemcitabine and cisplatin (also known as gem/cis) regimen are designed to kill or slow growth of bladder cancer cells. Goals of therapy: Cisplatin plus gemcitabine is given to shrink bladder tumors and decrease symptoms from bladder cancer.
What cancers does cisplatin treat?
Cisplatin, a chemotherapy drug, is best known for curing testicular cancer. It is also used in the treatment of a wide range of other cancers, including lung, bladder, cervical, and ovarian cancers. Cisplatin and other similar platinum-based drugs were developed with National Cancer Institute (NCI) support.
How effective is gemcitabine and cisplatin?
Cisplatin plus gemcitabine significantly improved progression-free survival, with a median of 8.0 months (95% CI, 6.6 to 8.6) in the cisplatin–gemcitabine group as compared with 5.0 months (95% CI, 4.0 to 5.9) in the gemcitabine-only group (P<0.001).
How long do you give cisplatin and gemcitabine?
Gemcitabine 800 mg/m2 was administered as a 30-min infusion on day 1, 8 and 15, and cisplatin 50 mg/m2 over 1 hour on day 1 and 8; in case of the 24-hour time interval the second drug was administered one day later.
How are cisplatin and gemcitabine used to treat bladder cancer?
If metastatic disease is present (cancer has spread beyond the bladder to other areas of the body), cisplatin and gemcitabine are not commonly given with the goal of cure, but rather to shrink tumors, decrease symptoms from bladder cancer, and prolong life. Gemcitabine intravenous (I.V.) infusion over 30 minutes on Days 1, 8, and 15
How long does a cisplatin infusion take to work?
Cisplatin I.V. infusion over 1 hour on Day 2 (or Day 1, if recommended by your Doctor) Up to two hours for Day 1 of each cycle; as short as one hour for Days 8, and 15 of each cycle Typically, I.V. hydration is given both before and after cisplatin and can add up to two hours on Day 1
What is gemzar + cisplatin?
Gemcitabine (Gemzar®) + Cisplatin is a Chemotherapy Regimen for Bladder Cancer How does gemcitabine + cisplatin work? Each of the medications in the gemcitabine and cisplatin (also known as gem/cis) regimen are designed to kill or slow growth of bladder cancer cells.