How are biodegradable polymers used in drug delivery?
Since then, the use of degradable polymers in drug delivery applications has become prominent due to their biocompatibility and degradability properties, as they can break down inside the body to produce nontoxic natural byproducts such as water and carbon dioxide, and are thereby easily eliminated.
Which polymer is used in controlled drug release?
Most of the materials used in swelling-controlled release systems are based on hydrogels, which are polymers that will swell without dissolving when placed in water or other biological fluids. These hydrogels can absorb a great deal of fluid and, at equilibrium, typically comprise 60–90% fluid and only 10–30% polymer.
How can polymers be used as controlled release devices?
Polymers have played an integral role in the advancement of drug delivery technology by providing controlled release of therapeutic agents in constant doses over long periods, cyclic dosage, and tunable release of both hydrophilic and hydrophobic drugs.
What polymers are used for drug delivery?
Among the synthetic and biodegradable polymers, aliphatic polyesters such as poly (glycolic acid), poly (lactic acid), poly (caprolactone) and polydioxanone, are most commonly used and applied to drug delivery systems.
What are the advantages of controlled release drug delivery systems?
Controlled drug-delivery systems offer numerous advantages over conventional dosage forms, including improved therapeutic effects, reduced toxicity, and increased patient compliance and convenience [1].
Which of the following is biodegradable polymer?
Cellulose is a biodegradable polymer.
What type of polymer would you use to attach a hydrophobic drug?
Thermosensitive hydrogels are usually triblock polymers made up from poly(ethylene glycol) (PEG) linked to hydrophobic polymer blocks.
What makes polymers biodegradable?
Biodegradable polymers are defined as materials whose chemical and physical characteristics undergo deterioration and completely degrade when exposed to microorganisms, aerobic, and anaerobic processes [2].
Which of the following is disadvantage of controlled release drug delivery system?
Table 4
| Advantages of Controlled DDS | Disadvantages of Controlled DDS |
|---|---|
| Long residence of drug | Invasive procedure to implant or remove the system |
| Protection from metabolism by enzymes/chemicals | Uptake by RES reduces efficacy |
| Improved bioavailability | Poorer IVIVC |
| Low dosing frequency | Limited standards |
What is difference between sustained release and controlled release?
Extended-release dosage consists of either sustained-release (SR) or controlled-release (CR) dosage. SR maintains drug release over a sustained period but not at a constant rate. CR maintains drug release over a sustained period at a nearly constant rate.
What is a biodegradable polymer give an example?
Polymers which disintegrate by themselves over a period of time due to environmental degradation by bacteria etc. are called biodegradable polymers. An example of biodegradable aliphatic polyester is PHBV i.e., poly −β− hydroxybutyrate-co-β− hydroxyvalerate. Chemistry.
What are biodegradable polymers give two example?
An example of biodegradable polymers are: Poly β-hydroxybutyrate–co-β-hydroxy valerate (PHBV). It is formed by combining 3-hydroxy butanoic acid and 3-hydroxy pentanoic acid. Other examples include polyglycolic acid(PGA), Polyhydroxy butyrate (PHB), Polycaprolactone(pcl), Nylon-2-nylon-6.