What is MUC1 protein?
MUC1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and several other organs.
Where is MUC1 expressed?
The MUC1 gene encodes a type-I transmembrane glycoprotein that is expressed on the apical surface of most simple epithelia, including mammary gland, female reproductive tract, lung, kidney, stomach, gall bladder, and pancreas as well as some non-epithelial cell types [reviewed in [1]].
Is mucin a protein?
Mucins and mucin-like molecules are highly O-glycosylated proteins present on the cell surface of mammals and other organisms. These glycoproteins are highly diverse in the apoprotein and glycan cores and play a central role in many biological processes and diseases.
Is EMA the same as MUC1?
MUC1 is also known as CD227 or epithelial membrane antigen (EMA).
What does EMA positive mean?
EMA is frequently positive in meningioma, which can be useful when distinguishing it from other intracranial neoplasms, e.g. Schwannomas. The absence of EMA can also be of value since negative EMA is characteristic of tumors such as adrenal carcinoma, seminomas, paraganglioma and hepatoma.
How do mucins work?
Mucins’ key characteristic is their ability to form gels; therefore they are a key component in most gel-like secretions, serving functions from lubrication to cell signalling to forming chemical barriers. They often take an inhibitory role.
Which type of protein is mucin?
Box 1. Mucins consist of a protein backbone, termed “apomucin”, covered with many O-linked oligosaccharides and a number of N-glycan chains. Mature mucin glycoproteins often undergo many post-translational modifications, including glycosylation, sialylation and sulfation, often in a cell-type specific manner.
What is EMA on pathology report?
Epithelial membrane antigen (EMA), also known as mucin 1 (MUC1), is expressed by epithelial cells of all types, mesothelial cells, perineural cells, and a subset of plasma cells.
What is EMA in a biopsy?
Epithelial Membrane Antigen (EMA) antibody stains normal and neoplastic cells from various tissues, including mammary epithelium, sweat glands and squamous epithelium.
What is the difference between mucus and mucins?
Mucins are glycoproteins which are components of mucus. Mucus comprises only mucins but is associated with other components such as anti-microbial peptides secreted by epithelial cells.
What are the types of mucins?
Histochemically mucins are classified into two types: Epithelial mucin (mucins/mucosubstances) and Connective tissue mucin (mucopolysaccharides). Epithelial mucins are further classified as neutral and acidic.