What is the laboratory findings of hereditary spherocytosis?
Testing for hemolysis is also appropriate in all patients. This includes lactate dehydrogenase (LDH), indirect bilirubin, haptoglobin, and reticulocyte count. Findings consistent with hemolysis include increased LDH and indirect bilirubin, decreased or absent haptoglobin, and an elevated reticulocyte count.
How is Hypoproliferative anemia diagnosed?
Hypoproliferative anemia is characterized by an inappropriately low reticulocyte count and is distinguished from anemia secondary to blood loss or peripheral erythrocytes destruction, which are accompanied by elevated reticulocyte counts from a bone marrow regenerative response.
What does increased osmotic fragility mean?
Spherocytic red blood cells have a decreased capacity to expand, and will rupture in mildly hypotonic conditions that fail to lyse normal red cells. They thus exhibit increased osmotic fragility. Osmotic fragility is determined by measuring the degree of hemolysis in hypotonic saline solution.
What is Hypoproliferative normocytic anemia?
Hypo-proliferative anemia is an anemia where the bone marrow’s response, the production of reticulocytes, is absolutely low, or low for the degree of anemia (Reticulocytopenia).
What does spherocytes mean?
Hereditary spherocytosis is an inherited blood disorder. It happens because of a problem with the red blood cells (RBCs). Instead of being shaped like a disk, the cells are round like a sphere. These red blood cells (called spherocytes) are more fragile than disk-shaped RBCs.
How do you test for spherocytosis?
A blood draw will be done to get a complete blood count, an immature red blood cell (reticulocyte) count, and a look at the shape of red blood cells to look for spherocytes. It is also important to rule out autoimmune hemolytic anemia. This can be done with a direct antiglobulin test.
What is a normal reticulocyte count?
Understand your reticulocyte Count results The normal, healthy range in adults is from 0.5% to 1.5%. Nevertheless, your doctor will help interpret this and recommend next steps. If the results show the reticulocyte abnormal, this will be because of a: High reticulocyte count (also referred to as reticulocytosis).
What is the range of red cell distribution width?
Red cell distribution width (RDW) Percent < 15 Reticulocyte count Percent of red cells 0.5–1.5 Reticulocyte hemoglobin (CHr) pg/cell 27–33 Total blood volume (TBV) mL/kg 65–85+; 55–75# Plasma volume (PV) mL/kg 39–44 Red cell mass (RCM)
What is a normal range for a white blood cell differential test?
White Blood Cell Differential (Diff) Test Meaning Normal Range Values Neuts.# (ANC) Absolute Neutrophil Count 1.70-7.00 x 109/L Lymphs# (ALC) Absolute Lymphocyte Count 1.00-4.80 x 10 9 /L Monos# Number of Monocytes 0.30-0.90 x 109/L Eos# Number of Eosinophils 0.05-0.50 x 109/L
What is the normal range of hemoglobin concentration in red cells?
Mean cell hemoglobin concentration (MCHC) g/dL red cells 33–36 Red cell distribution width (RDW) Percent < 15 Reticulocyte count Percent of red cells 0.5–1.5 Reticulocyte hemoglobin (CHr)
What is the normal range of platelets and red blood cells?
Plasma volume (PV) mL/kg 39–44 Red cell mass (RCM) mL/kg 25–35 Platelet count 103/μL or 109/L 175–450 White cell count (WBC, WCC) 103/μL or 109/L 4.8–10.8 Absolute monocyte count 103/μL or 109/L 0.3–0.8 Absolute neutrophil count 103/μL or 109/L 1.8–7.7 Absolute lymphocyte count 103/μL or 109/L 1.0–4.8 CD3-positive lymphocytes 103/μL or 109/L